The middle part of the Fairpoint Member of the Fox Hills Formation in Meade County, South Dakota consists of marine shoreface deposits and contains a chondrichthyan assemblage that includes both pelagic and bottom-feeding forms. The assemblage consists of genera (e.g., Rhombodus, Carcharias, Serratolamna, Ischyrhiza) widely known from Upper Cretaceous rocks of the Western Interior, and from other parts of North America, Europe, Africa, and Asia. This middle Fairpoint assemblage contains many of the same chondrichthyan genera reported by Cicimurri (1998) from the lignitic Stoneville lithofacies of the upper part of the Fairpoint Member. Fairpoint chondrichthyans are probably roughly equivalent in age to the chondrichthyans from the Timber Lake Member of the Fox Hills Formation in North Dakota, and are probably older than the chondrichthyan assemblage from the Breien Member of the Hell Creek Formation. The Breien, Timber Lake, and Fairpoint chondrichthyans are the youngest transitional marine chondrichthyan assemblages yet recovered from Cretaceous rocks of the Western Interior. The Fairpoint Member assemblage consists of chondrichthyan species different from those of the Paleocene Cannonball Formation of North Dakota. This disparity supports Cvancara and Hoganson's (1993) and Hoganson and Murphy's (2002) views that there was a significant turnover among Western Interior chondrichthyans during the interval between the deposition of these units. The cause of this turnover is not yet clear.